Monday, October 20, 2014


This supp is given to Cotton and me only twice a week, one capsule each. Coenzyme Q10 (CoQ10 for short) is mainly for the heart. Mom ordered the brand Garden of Life for us as its her fav. brand of supps since its whole-food supp instead of the common cheap synthetic ones out there. Ordered on 07 Oct at about USD37.76 per bottle before discount.

This ( link ) here is pretty detailed about it. Another link listed below.

COENZYME Q10 (CoQ10) for Pet Heart Health

Written by   

There are several natural treatments for heart disease in cats and dogs, including Taurine, Carnitine, Hawthorn and Coenzyme Q10. This month we are focusing on the use of CoQ10 for your pet’s heart health.
CoQ10 (ubiquinone) is a powerful fat-soluble antioxidant that is found in every cell in the body. It plays a fundamental role in the mitochondria, the parts of the cell that produce energy from food. Coenzyme Q10 appears to control the flow of oxygen within the cells as well as functioning as an antioxidant to reduce damage to cells by harmful free radicals. Every cell in the body needs CoQ10, but there is no US Recommended Dietary Allowance since the body can manufacture CoQ10 from scratch.

Because CoQ10 is found in all animal and plant cells, we obtain small amounts of this nutrient from our diet. However, it would be hard to get a therapeutic dosage from food. CoQ10 appears to assist the heart muscle during times of stress, perhaps by helping it use energy more efficiently. While CoQ10’s best-established use is for congestive heart failure, ongoing research suggests it may also be useful for other types of heart problems and for a wide variety of additional illnesses. Preliminary research has shown reduced levels of CoQ10 in the hearts of people and pets with heart disease.

In people, the typical recommended dosage of CoQ10 is 30 to 300 mg daily, often divided in two or three doses. CoQ10 is fat-soluble and is better absorbed when taken in an oil-based soft gel form rather than in a dry from such a tablets and capsules. In pets, the typical dosage is 30 mg every 24 to 48 hours, although your veterinarian may alter this dosage depending upon your pet’s size and individual needs. (Some doctors feel that increasing the dosage is necessary for larger pets; for example, 80 mg every 24 to 48 hours might be recommended for a 100-pound dog.) In people, the best-documented use of CoQ10 is for treating congestive heart failure and when taken along with conventional medications, not instead of them. People with congestive heart failure have significantly lower levels of CoQ10 in their heart muscle cells than healthy people. While this does not prove CoQ10 supplements will help people with heart failure, it has prompted researchers to try using CoQ10 as a treatment for heart failure. In people, at least nine double-blind studies have found that CoQ10 supplements can markedly improve symptoms and objective measurements of heart function when they are taken along with conventional medication.

Weaker evidence suggests that it may be useful for cardiomyopathy (several small studies suggest CoQ10 supplements are helpful for some forms of cardiomyopathy) and other forms of heart disease. It has also been suggested as a treatment for high blood pressure (although scientific evidence for this use is weak) and to prevent heart damage caused by certain types of cancer chemotherapy (such as adriamycin). Since CoQ10 might conceivably interfere with the action of other chemotherapy drugs due to its antioxidant activity (although there is no good evidence that it does so), check with your veterinarian before using CoQ10 if your pet has cancer that requires chemotherapy.

CoQ10 may also help periodontal (gum) disease (by reducing the size and improving the health of periodontal pockets, as well as decreasing inflammation, redness, bleeding, and pain) and diabetes in people and pets. Since most pets with heart disease also have periodontal disease, an extra benefit might be achieved in pets with heart disease taking CoQ10.

In experiments in dogs, CoQ10 was found to exert a protective effect against oxidative injury to the heart. Stabilization of body weight, improved clinical status, and a slowing of the progression of signs have been seen in dogs with heart disease treated with CoQ10.

CoQ10 appears to be extremely safe. No significant side effects have been found; however, pets with severe heart disease should not take CoQ10 (or any other supplement) except under a veterinarian’s supervision.
The maximum safe dosages of CoQ10 for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been determined; the same is true for pets of similar circumstances.

Sunday, October 19, 2014

Organic Mushroom Complex

It's Mom's Rei-ki Teacher who recommend a mushroom supplement for Chewy. She's crazy over cats btw and rescues them and most importantly, very knowledgeable on raw food/holistic health for animals. So whenever Mom's at the seminar, she's always asking her qns on animals and never on humans lol. Ah btw Mom's teacher is like the queen of supplements eating over 30 capsules a day or maybe even more.

Again, Mom researched and found this organic mushroom complex by Dr. Mercola for us. Ordered it on 23 Oct and it's around USD20.37 per bottle before discount. We're fed probably about 1/3 of a teaspoon each 6 days a week (Mondays are our fasting days).

Here's the ( link ) to all the details.

Saturday, October 18, 2014

Organic Blueberries . Blueberry Extract .

Other than organic apples and organic kiwis (awesome for vit. C), we also get organic frozen blueberries. Blueberries are mega high in anti-oxidants which are awesome for living beings. Btw, blueberries should preferably be frozen for a reason (more on it below). Mom has been freezing all our blueberries years ago even before reading those recent articles published on the benefits of freezing blueberries. Because if you do not freeze them, they'd turn all soft and alcoholic-like. Mom thinks its just common sense to freeze them. Or maybe some ppl don't like it frozen. Some brands have it stated on their packaging that they are to be kept frozen.

Mom also ordered blueberry extract on 07 Oct 2014. They're about USD16.88 each before discount. If you've come across bilberries, it's just another name for it... difference being bilberries are wild. Both are fine.

Mom blends our fruits too with our organic veg 6 days a week (we fast every Monday). Now its just either one organic kiwi per day or about 8 to 10 organic blueberries. If she uses the raw berries then blueberry extract would not be given vice-versa.

We get either one-quarter (or sometimes half) capsule each per day. No fixed rule... its up to you. Mom simply caps the capsule back and refrigerate it. Only the contents of the capsules are fed to us. So technically, Mom is super-pro in opening capsules LOL. 

14 Aug 2013

Can Dogs Eat Berries?


Most dog guardians today want to feed their dog a healthy diet, but  aren’t always sure exactly what foods are healthy.  Take berries, for example.  If you check the Internet, you will find lots of different information about berries.  People seem confused about whether or not berries are good for dogs, or even safe to feed dogs.  You can rest assured that there are many kinds of berries that are perfectly safe and healthy for your dog to eat.

Dogs Love Berries

Dogs love many of the same kinds of berries that you probably like yourself:  blueberries, cranberries, raspberries, blackberries, and strawberries.  All of these berries are healthy and safe for your dog to eat.

Some Poisonous Berries

When people refer to berries that dogs should avoid, those berries include fruit that contains pits, such as cherries.  It is possible for a dog to choke on these large pits or “stones.”  Additionally, some of these pits contain chemicals which can be harmful to your dog if eaten.  Dogs should also avoid eating holly berries, juniper berries, baneberries, poke berries, and mistletoe berries.

Health Benefits of Berries

Just as there are health benefits for you when you eat blueberries and other berries, there are also lots of health benefits for your dog.  Berries are known for their antioxidant properties, which means that they can protect your cells against the effects of “free radicals.”  Free radicals are normally produced when your body goes through the process of breaking down food, or whenever it’s exposed to many everyday assaults from things like tobacco smoke or ordinary radiation in the atmosphere.  Free radicals can cause damage to our cells.  It is believed that these harmful molecules can affect us in ways that cause cancer, heart disease, and other health problems.  So, antioxidants which come from berries, can help protect us, and our dogs, from the harm caused by free radicals.  Giving your dog berries may help prevent cancer, heart disease, and other health issues.

Studies have also suggested that blueberries are beneficial to older dogs and help them keep their cognitive functions.  This is especially important for dogs that might be experiencing canine Cognitive Dysfunction Syndrome.

Cranberries offer dogs the same benefits that they offer humans and can improve urinary tract health.  They are especially beneficial to dogs experiencing any kidney issues.  Cranberries are particularly high in vitamin C.  Cranberry juice is acidic and when you give it to your dog it helps to lower the pH of your dog’s urine.  This makes the urinary tract inhospitable for bacteria.

Trying Berries

Many dogs enjoy eating berries right from your hand, or you can put some berries in their dish with their dog food.  In other cases, as with cranberries, you can give them some cranberry juice to add berries to their diet.  Berries can be fed in berry form, pureed, or you can add them to a favorite dog cookie recipe.  Berries also make excellent treats for your dog.

If you haven’t offered your dog berries yet, purchase a couple of different kinds and see how your dog likes them.  Chances are that your dog will quickly become a big fan of berries.  And you’ll be a big fan of their health benefits to your dog.

I think we’re all already aware that organic berries are very good for our overall health. The vitamins that they contain spread a number of benefits throughout our body, but is it possible to make them even more healthy?

Apparently, yes. Yes we can.

More and more research is pointing in the direction that freezing fruits can actually make them even healthier. This appears to be the case with organic blueberries, where anthocyanin concentration is actually more potent after a short stay in the freezer. In case you don’t know, anthocyanins contain a number of anti-inflammatory qualities, and are known to benefit your overall brain health.

Some research even suggests that anthocyanin may possess anti-carcinogenic properties that could completely revolutionize the medical industry.

What does freezing do?
When you freeze blueberries (for short OR long periods of time), the low temperatures penetrate deep within the fruit and disrupt the tissue structure – this makes the anthocyanins more available and absorbable.
The berries actually have their sharp, blue color because of the anthocyanin in the tissue. Organic berries already have higher nutritional content than alternatives, but freezing them can actually improve on these 5 benefits:

1.      Improving Heart Health

Eating frozen blueberries can significantly lower your risk of heart disease. This is because the nutrients regulate and relax the elasticity of your arteries in the vascular wall, keeping them from getting damaged. Consequently, this also improves your blood flow, giving you a healthy blood pressure in the process.

2.      Reduced Risk of Alzheimer’s Disease & Other Forms of Dementia
The anthocyanin in the berries can actually improve your memory functions, and protect your brain against cell damage and loss. The protection makes your encoding and retrieval processes more fluid, making it easier to recall information.The berries can also improve your nerve cell growth, and make communication easier between nerve cell processes. This actually slows down the rate that they age, and ultimately, die.

3.      Improved Nervous System Health
The antioxidants in blueberries  provide your nerve cells with protection, as mentioned previously. They also keep your brain healthy from various forms of toxin pollution that it is exposed to every day. They effectively create a safeguard around your nervous system to keep it healthy and strong for a longer period of time.

4.      Improved Motor Function
Older adults, who suffer from impaired movements above the age of 70+ years, generally perform and behave more functionally after consuming frozen blueberries. They have heightened cognitive ability, which shows improved motor ability in comparison to other men and women in the same age group.

5.      Improved Digestion
The antioxidants in blueberries protect your digestive tract from any damage from outside sources. The scary thing is, many of the people who lack antioxidants in their diets consequently develop cancer as a result of poor gastrointestinal health. People at risk of developing colon cancer should definitely bring more frozen blueberries into their diets.

Blueberries are already so healthy, but freezing them allows for you to get the benefits in such a higher concentration than refrigerated ones. They will taste just as good, but will be so much healthier without even showing it.

Try them out next time you pick up a batch. Grab a few extra ones to pack into the freezer for a few weeks, and make them a regular start to your mornings.


Friday, October 17, 2014


Another one of our new supps is bio-curcumin which Mom ordered on 07 Oct 2014. Curcumin is the main compound found in turmeric. We've been eating organic turmeric for a long while now as curcumin not only aids in preventing cancer, but also helps in arthritis and Cotton has mild arthritis which thankfully has not worsen for a long time. Mom believes its thanks to curcumin. We're not on any glucosamine or MSM which ppl usually use for bone issues as Mom just doesn't ''feel'' like its for us. What we're fed with actually depends on Mom's hunches. If she doesn't feel like feeding it based on her intuition without any concrete reasons, then nope... we ain't getting it.

We get half a capsule each a day. Its about USD28.50 each before discount.

  • For Longer Life
  • Up To 7 times Greater Absorption†
  • Dietary Supplement
The 100% natural curcuminoids complex in Super Bio-Curcumin is patent-pending synergistic blend of curcuminoids and sesquiterpenoids with enhanced bioavailability and sustained retention time in the body confirmed by human clinical studies. Super Bio-Curcumin is a "next generation" in delivery of curcumin compounds that no longer requires high doses of curcumin to reach sustained levels of curcumin in the blood plasma. †Each 400 mg capsule of Super Bio-Curcumin is equivalent to 2,772 mg of a typical 95% curcumin extract.

Super Bio-Curcumin
Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable health benefits for nearly every organ system in the body … including its ability to inhibit enzymes that help produce inflammation in the body.

Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body.

Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body. Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).

Other clinical trials suggest roles for curcumin in helping maintain healthy bowel and joint functions. Curcumin can also help maintain normal healthy platelet function, and have immunomodulatory effects by inhibiting histamine release from mast cells. Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.

Curcumin may effectively support pancreatic islet health. Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals, protecting against free radicals, and promoting normal cell cycle growth.

The problem is that curcumin is poorly absorbed into the bloodstream. Super Bio-Curcumin absorbs up to seven times better than conventional curcumin. So this patented formula represents the most cost-effective way to supplement with this critical nutrient. Studies show that one 400 mg capsule a day of this turmeric compound can provide curcumin blood levels equal to ingesting 2,500–2,800 mg of commercial curcumin supplements. And not only does this turmeric formulation provide far greater peak blood levels, but the curcumin remains in the bloodstream almost twice as long as conventional supplements. And this enhanced absorption delivery complex provides other beneficial turmeric compounds in addition to standardized curcumin.
Suggested Use
Read the entire label and follow the directions carefully prior to use.
Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.
Other Ingredients
Rice flour, vegetable cellulose (capsule), vegetable stearate, silica.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten or corn. Contains NO sugar and no artificial sweeteners, flavors, colors or preservatives.
Caution: Do not take if you have gallbladder problems or gallstones. If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Store tightly closed in a cool, dry place.

u can also use organic turmeric powder

If you cook, you may already be familiar with turmeric, but for first timers, here’s a quick culinary lesson to get us started. The turmeric herb, a member of the ginger family, is most commonly known for its deep orange color and is used for cooking, herbal medicine and dyes. Native to Middle Eastern and Southeast Asian countries, it has been a staple in cooking for thousands of years. Today it is a key ingredient in most curry dishes as well as yummy Thai, Indian, and Persian plates.
Ayurvedic and Chinese medicines have long known the benefits of turmeric for the body, inside and out.

“Ay….ur…vedic medicine?”

Quick explanation. An ancient Ayurvedic proverb reads: “When diet is wrong medicine is of no use. When diet is correct medicine is of no need.” Ayurvedic medicine is the traditional medicine of India, originating over 5000 years ago. How is this relevant today? Because it doesn’t just look at the aspect of treatment, it looks at prevention and using elements like nutrition, exercise and lifestyle factors to re-establish balance in the body.

What we eat is a key component of this holistic healing approach.

Spice of Life

OK, back to turmeric. So we know that it’s a spice. It’s orange. We cook Eastern and Asian food with it. But why is it so good for our pets? The bio-active compound (active ingredient or healing properties) of turmeric is “curcumin” (not to be confused with a different spice called cumin). Curcumin is responsible for its bright orange color as well as a host of health benefits. This prime ingredient acts as a spice, but also as a pain reliever. For this reason, it’s a great food additive for pets that suffer from ailments and illnesses which cause pain.
But it’s also beneficial in many other ways! Let’s look a little closer at Eastern medicine to understand how it is used to maintain good health.
Traditional Asian medicine used turmeric for its ability to detoxify the body, purify the blood, stimulate bile production in the liver, disinfect wounds, and as a stomach tonic. In addition, Thais used it to treat diarrhea and other stomach ailments, as well as to eradicate ringworm, a fungal infection. In Afghanistan and Pakistan, turmeric is applied to wounds to cleanse and stimulate recovery, keeping harmful bacteria away.


Western medicine is finally catching up with Eastern practice. Turmeric is now being researched extensively for pharmacological use in treating and/or reducing symptoms related to a wide range of health conditions. The National Institute of Health is conducting 19 clinical trials on turmeric and curcumin. A paper written for the American Academy of Pain Management discusses the health benefits of turmeric. “Turmeric is one of the most potent natural anti-inflammatories available,” says Dr. Randy J. Horwitz, the medical director of the Arizona Centre for Integrative Medicine and assistant professor of clinical medicine at the University of Arizona College of Medicine.

Dr. Horwitz also cites a 2006 University of Arizona study that found this potent anti-inflammatory to reduce the symptoms associated with rheumatoid arthritis. Clinical studies have shown that curcumin in turmeric is a powerful antioxidant. Antioxidants neutralize free radicals which cause the painful inflammation and damage to joints affected by arthritis.

This is pretty significant for our senior K9 friends that may be suffering from the aches and pains associated with arthritis and aging in general.

The anti-inflammatory properties, combined with the fact that turmeric is a natural antiseptic and antibacterial agent, suggests that it’s also useful for disinfecting and treating skin injuries. Research suggests that when using it topically, mix it with honey. This creates a paste that you can easily apply to wounds. We talked about raw honey before, so you probably already know that honey also has high antibacterial properties. Of course, you will have to keep an eye on your furry friend as the combination of turmeric and honey may also be a tasty treat.

Heart Health

Another concern with our senior pets is ensuring heart health. Like us, our pets are susceptible to blood clots and excess cholesterol. You may have heard of LDL (bad cholesterol) and HDL (good cholesterol). Well turmeric has been found to lower LDL levels which support both heart and liver health.
In addition, turmeric helps to thin the blood, reducing the risk of deadly clots that can lead to strokes and heart attacks. It’s important not to thin your dog’s blood too much, but the right amount can be helpful. If your pet is on medication, especially those that thin the blood, check with your vet for the appropriate dosage.

The Great Detoxifier

What about the liver? Yes, turmeric is good for that too.
Our environment is becoming more and more toxic and that not only affects us, it impacts Fido as well. Our pets are susceptible to toxins in the environment and in their food, especially commercially produced kibble and treats.

The liver plays a significant role in removing toxins from the body. Think of the liver as the main industrial centre for the body. It’s involved in nearly every biochemical process required to run the body. The body’s abilities to clot blood, to breakdown harmful toxins, and to remove waste and store energy, are all affected by the liver. It is a major player in your pet’s digestion, storing vitamins and producing bile which is necessary to break down fat. It’s a pretty important piece of machinery for your pet’s overall health.

Curcumin is believed to stimulate bile production necessary for the digestion of fat in the liver. Active dogs need at least 20% fat in their diet; therefore, bile production is critical for good health.

In short, turmeric boosts the liver’s ability to metabolize fat and remove waste from the body.

As with any pre-existing condition, if your pet already suffers from liver disease, you should consult your vet before treating with turmeric as some studies indicate that turmeric may aggravate existing problems.
Anti-Cancer Properties!!!

One of the most interesting discoveries I made while investigating the benefits of turmeric is that there are now reports coming out claiming that turmeric may help in the fight against cancer! This powerful antioxidant plays a significant role in preventative medicine.

But wait, there’s more!

In a study at UCLA, doctors found that curcumin seemed to block the cancer promoting enzyme that stimulates the growth of head and neck cancer. The Department of Small Animal Clinical Scientists has conducted studies that show that curcumin can inhibit tumor growth and may even shrink existing tumors. This has to do with the spice’s amazing ability to shut down blood vessels that feed tumors.

Antioxidant properties are also helpful in reducing the negative side effects of chemotherapy.

Now, we are not saying turmeric is the only thing you should do to prevent, control and/or treat cancer; however, it certainly has us excited about its anti-cancer properties.

Other Uses

If we haven’t already convinced you about the health benefits of turmeric, here are a few more uses:
  • Aids in the treatment of epilepsy
  • Helps relieve allergies
  • Helps in preventing the formation of cataracts
  • Used in treating depression (Yes, dogs can get depressed too)
  • Kills parasites
  • Heals stomach ailments, aids in digestive disorders, and reduces gas and bloating
  • Acts as a binding agent and therefore great for treating diarrhea (Make sure you have lots of water available for your pet to drink!)
  • Aids in fat metabolism and weight management
  • High in fiber and rich in vitamins and mineral

So How Do I Feed It?

The suggested dosage is approximately 15 to 20 mg per pound of body weight in dogs, 150-200mg for cats. A simpler way of looking at it is an 1/8 to a 1/4 teaspoon per day, for every 10lbs of dog weight. Make sure your pet has lots of water to ensure that they don’t get constipated.

You can feed the powder, which is most commonly available, or crushed or fresh root. Sprinkle it right on top of your pet’s food and mix or, if you home cook, you can add it to the recipe. Quality varies and if you are buying turmeric in a local supermarket, it may be grown using nasty pesticides and herbicides. This lowers the potency. If possible, try to get high quality, organic turmeric. Be sure to store it in a tightly sealed container, kept in a cool, dark and dry place.

According to Dr. Demian Dressler, DVM known as the “Dog Cancer Vet” and author of Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog’s Life Quality and Longevity: “[…] curcumin has some bioavailability problems. This means that the stuff doesn’t, to a large extent, get absorbed into the blood after it is taken by mouth. However, there are ways around this.

Curcumin does not dissolve well in water. This is one of the things that limit its absorption. You can overcome this by mixing it with lecithin and water and making a slurry. Lecithin is available online. It is very, very gooey, so you must add some water to the curcumin-lecithin (about 4 parts water to 1 part lecithin). You can put some low sodium boullion, or similar agents, in it for flavor. Many of the commercial preparations have bromelain with it to enhance blood levels. No problem. Doses are approximate, and taken from human literature. For a large dog, use about 2 grams twice a day.”

Is There Anything Else I Should Know?

Remember how turmeric is a bright orange color? Well, the ancient monks used turmeric as a dye to stain their robes. Moral of the story: be careful and mix it in well with your pets’ food, because your pets might end up with turmeric mustaches!

Turmeric is a binding agent, so ensure that your pet has lots of water to reduce the likelihood of constipation.
Our research didn’t find many contradictions to taking turmeric medicinally. However, if your pet does have a pre-existing condition, is currently on medication, has a planned surgery, or is pregnant, it’s advisable to talk to your vet before feeding.

Spice up yours and your pet’s life with a little turmeric!

Written by Planet Paws Blogger – Sarah MacKeigan
Sources & Information – Rodney Habib
Editor & Photographer – Lise Blinn

Spice of Life: Curcumin and Dog Cancer

In researching topics for expanded treatments of dog cancer, I have discovered surprises aplenty.
Because of the desire for options beyond surgery, chemo and radiation for dog cancer, I chose to look in areas that I would have ignored just a few years back.

One of the hottest topics in cancer research right now is the dietary flavonoid group.  This is just a bunch of substances that are found in foods which have beneficial effects against cancer.

We all know that certain foods or dietary choices have influence on cancer development and overall health.  I came accross a statistic in human medicine that stated that about one third of cancers in people could have been prevented with lifestyle choices (this was excluding the effects of cigarette smoking).

One of the biggest lifestyle choices is the inclusion of certain foods that combat the effects of environmental carcinogens, genetic tendencies, trace water pharmaceuticals, viral DNA changes, dietary carcinogens, electrical field effects, and more.

Most of these naturally occuring flavanoids have very low toxicities.  One of the biggies is curcumin.
Curcumin is found in turmeric, which is the spice that is used in curries.  Curcumin is exceedingly interesting for dogs with cancer.  It is one of the core ingredients I use in cancer supplement programs for my patients and I have seen literal shrinkage of different dog lumps, like  hemangiosarcomas of the skin, fatty tumors (lipomas) , fibrosarcomas, and plasmacytomas.  I rely on it a lot.

This substance is being used as a model for tons of anticancer drugs  in development right now.  Here is some info.  And here is some more.  Over 40 different curcumin analogs (new drugs using curcumin as a template) are being researched at Ohio State University.

Why not just use the curcumin, instead of going through all the bother of making these new drugs?  There are two main reasons.

My grandfather left me these wise words: “When you want to find the reason for something, look for the dollar.”

So of course money has something to do with it.  You can’t patent a naturally occurring compound.  However, if you tweak its structure to produce a synthetic analog, get the lawyers together to protect the intellectual property, patent it, you are set for years. In this way big pharma protects profits.
Secondly, curcumin has some bioavailability problems. This means that the stuff doesn’t, to a large extent, get absorbed into the blood after it is taken by  mouth.  However, there are ways around this.

If you want to find out more about curcumin, please read the next post!!

Best to all,
Dr Dressler

More on Curcumin and Dog Cancer

In the last post, I introduced curcumin, a useful tool against cancer found in turmeric.
In this post we will look at some of the effects and practicalities in the use of this remarkable substance.
Safety should always be questioned. Curcumin is exceptionally safe when given by mouth.  Read more here.
One of the complaints about it is that it is not absorbed significantly when taken by mouth (passes through in the feces). True statement. But…

Curcumin taken by mouth does have effects in the body after all, in spite of low levels being taken up in the blood.  It was shown in  a human clinical trial that large doses (over 3 grams) decreased the levels of a chemical signal with links to cancer development and progression.

This chemical signal is called prostaglandin E2. This signal was measured in the bloodstream.
This means that actually some of the curcumin taken by mouth does indeed have effects on the body.  Check it out for yourself here.

Curcumin, at least in test tube studies (in vitro), shows a most definite ability to cause cancer cells to end their life cycle.  Another way of saying this is that it is an apoptogen, or something that causes programed, healthy,  end-of-life for cancer cells.

One way that curcumin is able to do this is by injuring the mitochondria, or the energy factories in the cancer cells.  Here is an abstract about that.

Curcumin is able to shut down the activity of one of the central chemical signals involved in cancer development and progression (NFK Beta).  This molecule is perhaps one of the most important molecules in the whole field of cancer.

On top of that, it has effects to slow the growth of blood vessels feeding tumors,  helping to stop cancer expansion.

For more info on these different ways curcumin helps fight cancer, read on here.

In humans, most of the research has focused on intestinal cancers.  The reason is because the stuff, after taken by mouth, goes down into the intestine and contacts the wall of the intestine.

Since these intestinal cancers are less dependant on curcumin getting in the blood to contact the cancer cells, that is where the interest has been.

I believe curcumin has broader application than that. Since we know it has effects outside the intestine, and it is non-toxic,  it should be applied more for dog cancer.

Curcumin does not dissolve well in water.  This is one of the things that limits its absorption.  You can overcome this by mixing it with lecithin and water and making a slurry.  Lecithin is available online. It is very , very gooey, so you add some water to the curcumin-lecithin, about 4 parts water to 1 part lecithin.
You can put some low sodium bullion in it for flavor, or similar agents.

Many of the commercial preparations have bromelain with it, to enhance blood levels.  No problem.
Doses are approximate, and taken from human literature.  For a large dog, use about 2 grams two times a day, as an estimation.

Do not use curcumin with gall stones, stomach ulcers, or within 10 days of surgery.

There is a possibility it should perhaps be avoided with liver problems in some references.  I believe this effect is not likely based on serial blood tests in my hospital with its use, but discuss with your vet, as always.

There is more in how curcumin fits into the full spectrum plan in the downloadable cancer book on

Best to all,
Dr D

Turmeric for Dogs, Cats 


Turmeric is such a remarkable natural remedy for people that pet owners are bound to try it for their dogs and cats as well. But is turmeric safe for pets? And is it an effective remedy for ailments in your cats, dogs, and other pets? Earth Clinic can help you find those pet care answers!

Curcumin, the principle active component in turmeric, is a potent anti-inflammatory and antibacterial agent that shows promise in the prevention and treatment of cancer and Alzheimer's Disease, among other conditions. And yes, it is generally found to be safe for dogs and cats.

Home Remedies: Vets frequently recommend the addition of turmeric to your dog or cat's diet if they have been diagnosed with cancer. Offer your pet up to a quarter of a teaspoon per day for every 10 pounds of your pet's weight. Turmeric can also be good for reducing arthritis inflammation and pain in pets!

Turmeric Spice: A Powerful Anti-Inflammatory Agent


By Dr. Becker
Today I want to discuss turmeric, which is a bright yellow spice plant with the scientific name Curcuma longa.

Curcuma longa

Curcuma longa is a perennial plant in the ginger family. It grows about five to six feet high, has a trumpet-shaped, dull yellow flower, tough brown skin, and a deep orange flesh.
Turmeric has a fragrant aroma and a bitter, slightly sharp taste. It grows in many tropical regions but the majority is grown in India, where it is used in curry.
The active ingredient in turmeric is curcumin, found in the roots and bulbs. They are typically boiled and then dried, which results in the yellow powder most of us are familiar with.

Turmeric Provides Benefits to Both Humans and Animals

Turmeric has been used for thousands of years in Ayurvedic and Traditional Chinese Medicine (TCM).
A growing body of more recent Western and holistic medicine evidence shows that turmeric is a preventive agent for a wide range of diseases, thanks to its anti-inflammatory effect.
In both humans and animals, turmeric has been shown to:

Enhance antioxidant protection against free radicals Balance the digestive tract
Promote healthy skin and eyes Promote healthy blood and circulation
Provide and support a healthy immune system Maintain normal cholesterol levels
Promote joint health Improve stress tolerance
Encourage healthy liver function Maintain healthy blood sugar levels within normal range

Curcumin’s Disease Prevention and Healing Properties

The list of curcumin’s preventive and healing properties is a long one. According to an overview published in 2007 of a study conducted at M.D. Anderson Cancer Center’s Department of Experimental Therapeutics1:
“Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a really significant potential effect against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses.”
Also in 2007, ethnobotanist James Duke published a comprehensive summary of turmeric studies in Alternative and Complementary Therapies2. Duke reviewed around 700 studies that concluded: “… turmeric appears to outperform many pharmaceuticals in its effects against several chronic debilitating diseases, and does so with virtually no adverse side effects.”
One of the conditions turmeric has been found to be beneficial for is arthritis. Turmeric contains more than two dozen anti-inflammatory compounds, including six different COX-2 inhibitors. The COX-2 enzyme promotes pain, swelling, and inflammation, so inhibitors selectively block that enzyme.

Studies of the usefulness of curcumin have demonstrated positive changes in arthritic symptoms.
Duke found more than 700 citations for curcumin and cancer as well. He noted that in the handbook Phytochemicals: Mechanisms of Action, curcumin and/or turmeric were effective in animal models in prevention and/or treatment of colon cancer, mammary cancer, prostate cancer, and liver cancer in rats.

Researchers at Colorado State University’s Animal Cancer Center are evaluating the potential for curcumin to treat feline cancer, specifically feline vaccine-associated sarcoma3.
Researchers at Vanderbilt University have found curcumin to be very beneficial in slowing the progression of autoimmune diseases in the animal model4.

Supplementing Your Pet’s Diet with Turmeric

As you can see, potentially all mammals can benefit from this amazing spice.
Most dogs and cats readily accept a little seasoning on their meals. I have also found that all my pets, including my birds, do fine with the fresh root grated over their food.

If you want to increase the amount of biologically available curcumin in your pet’s diet, you’ll need to go with a supplement. I recommend you look for a high-quality, organic turmeric product and consider giving cats about 100 milligrams twice a day. Small to medium-sized dogs can be given 250 milligrams twice a day, and large to giant breeds should get 500 milligrams two to three times a day.

As always, you’ll want to discuss the exact amounts needed for your individual pet with your holistic veterinarian.

Monday, October 6, 2014

Kranji Farms

We (including the grams) went to a few farms in Kranji including the organic veg farms to get our veg! Cool place and we'll be back there again!

Dogs are also allowed at the cafe because the owner has over 10 dogs of her own! Big ones. Although the cafe isn't vegan, but they do customize the dishes to be vegan. Mom's fav is the fried moringa. Not so healthy but awesomeeeee she says. No I didn't get any since they're deep-fried.

flowers flowers!

eyeing those big in-house doggies

we all love coco-nuts!

we are ''For Sale but only to rich foreigners!'' LOL

just minding our own businesses.........

there's over 10 more inside the villa! with a huge pond too

awesome place......

grandpa kept telling mom to look out in case we fall into the pit
behind. LOL

Tuesday, September 30, 2014

Soft Lump On My Inner Trunk and Surgery

On Apr 1st (yea april's fool but not!), Mom saw a tiny area of black ''dirt'' (or so she thought) on my left inner trunk so being itchy-fingers her, she tried to ''dig'' it out. It did not not come off, but also turned into a ''bubble''! So Mom was shocked. Pictures later on.

The ''bubble'' was pinkish and really soft. It was sticking outta my skin and it can move left right up down wherever.....

So Mom thought that we would just monitor it. She sprayed colloidal silver on it etc and reiki-ed it too. It soon became blackish but still real soft and ''bubbly''. After that it kinda became flatter and dryer like a tick.

We went for our annual bloodwork in Aug and had the vet have a look at it. She didn't thought it looked good. Her words, ''the color is worrying and it could be cancerous.'' We did a Fine Needle Aspirate (FNA) to try draw some cells out to have a look but since the lump was SO tiny and soft, no cells could be drawn out. Well, a teeny weeny amount actually, which she says she thinks it wouldn't be enough to see anything. Better not to waste the money sending it to the lab.

So her next suggestions were:

1) Go under a light sedation to remove a portion of it (note that its already SO TINY in the first place) and send it for biopsy the nature of the lump or whether its cancerous anot etc. Results would then determine how much area to remove so it would have a safe margin. Meaning go under GA TWICE. This would cost roughly $700+ for the 1st surgery and $900+ for the 2nd surgery. Excluding GST etc. Not sure if it includes cost of biopsy.

2) Remove the entire lump at one go and send it for biopsy. Risk in this is if it turns out cancerous and the marginal area is not removed enough then a 2nd surgery is needed to remove more.

So Mom made an appt with this vet for the 1st option. As to why she wants to remove it... because any lumps on the body has a chance of turning cancerous if left long enough. But upon 2nd tots and advice from cushla's mom... she decided to ask this vet for a referral letter (paid S$32.10 for it) to a specialist, Dr. Landon for a 2nd opinion. Afterall, a specialist eyes and hands are way better. You need a referral letter to see Dr. Landon btw. He is a specialist in orthopedic.

Of we went to Dr. Landon and guess what?! One look and touch at it and he said its definitely NOT cancer and its just a minor issue. Although it hasn't grown since Apr, it's still best to remove it since its on my inner trunk. Cuz if it grows in future, it might get caught in grass etc if I run around alot. If it were on say my back, it would be less of a hassle. It would be also more difficult to remove it if it grows much bigger in future. Since Dr. Landon was confident its more of a non-issue and a benign lump, it means surgery is not urgent. But Mom just wants to get it done and over with.

Dr. Landon's consultation fee is really ex at S$160.50 but Mom thinks its totally worth it for more specialized eyes and hands.

Mom booked an appt with him for the surgery. He said it would be a quick one except waiting for me to wake up from the GA.

Surgery was on the morning of 18 Aug 2014. Mom walked me around the estate there for an hour before sending me in to be sedated. I think I was sent in at 10am and Mom waited there. I was out and running at 12pm! Yes! Out and the first thought on my mind (aside from Mom) was my white kitty cat outside the clinic! I even jumped around in the car backseat frontseat to and fro! Mom almost fainted.

So biopsy was done and Dr. Landon informed Mom of the results. All's good and well. Went back 2 weeks later to remove my stitches too as well as get the report. Ah did Mom mention that the stitches were done REAL NEAT AND GOOD?! Dr. Landon told Mom to NOT let me jump up and down for 2 weeks but I did the opposite.

Ok pictures time.

10 Apr

17 Aug day before surgery

18 Aug. Just before surgery!

for Mom to sign

couple hours later... my lump sent for biopsy. its at the corner of the bottle.

can't wait to see kitty cat! they tied a cute ribbon on me lol. not that i care

this cat! right outside the clinic!
i think she's the leader of the pack

back at home

24 Aug

super neat stitches. how gd the stitches are affects us as well

i did not to wear the cone of shame too. mom's fwens were very surprised
but i guess it's mainly due to the well-done stitches which made me
feel pain-free. not once did i attempt to scratch/lick it.

1st consultation fee

Surgery fee. I'd say same price as normal vet's.
but under better hands.

biopsy results sent to Canada (if mom remembered correctly).
Best to send it overseas rather than locally.

Mom strongly believes in 2nd or even 3rd opinions. Especially so on Chewy's previous case as well. If Mom hadn't seeked other opinions, things wouldn't have gone so smoothly. Dr. Landon and his team are by far the most ethical (and best) vets Mom has come across by far. It's definitely worth the extra effort to seek their opinion in all matters. Dr. Landon even said he wishes everyone were like Mom, coming to him while the issue is still very minor, as oftentimes, it's too late to do anything.

So that's about it! Oh yea most vets have also said that I've cataract while others say its just Nuclear Sclerosis (typical aging of eye lens which does not affect sight, unlike cataract). Mom had Dr. Landon take a look and he said its the latter. Mom would rather believe him. So do u see...... so many conflicting opinions... makes Mom wish we could just walk-in to Dr. Landon for any issues rather than needing a referral letter from normal vets. 

Thursday, September 11, 2014


Mom bought RNA (Ribonucleic Acid) for us. It's about USD14.91 before discount. We eat about 10-ish different supplements a day on top of our 10-ish different organic veg smoothie per day. Some of the older supps which we have been eating for years like nutritional yeast is off the menu already.

Most (if not all) ppl think Mom as mad soon as they hear we eat tonnes of supps and veg. But the truth is, supplements are meant to support and assist a living body and never a cure for dis-ease. That's why its called supplements! Mom often reads about ppl saying things like, ''don't feed supps unnecessarily unless the dog really needs it.'' C'mon, once your dog really needs it, its kinda too late don't you think?  Why WAIT for dis-ease to set in then decide to feed supps? Why not feed supps all along to PREVENT dis-ease?

Think about it.

Anyways, for RNA, we all get half a capsule each daily (well, actually 6 days a week since we fast every Monday). It's really good for animals for its anti-aging properties. It's basically for healthy cells, think DNA and you'll get the idea. The younger an animal starts taking it, the better for them. It was actually Mom's rei-ki Teacher who recommended this RNA supp to Mom for us as she's very knowledgeable on diet for animals... she highly recommends organic raw food for animals as well.

So back to RNA... there's a few sites with some pretty good info. We will paste the entire stuff here just so in case the links get broken next time. It's so just for Mom's reference.

Mom ordered it on 01 Sept and we were on it about a week later. Oh btw, Chewy absolutely LOVES it. Being a cat, she can be pretty picky about supps. There're some that she doesn't fancy as much but RNA and probiotics are her favorite aside from the stinky krill oil.

What is RNA?

Ribonucleic acid, or RNA is one of the three major biological macromolecules that are essential for all known forms of life (along with DNA and proteins). A central tenant of molecular biology states that the flow of genetic information in a cell is from DNA through RNA to proteins: “DNA makes RNA makes protein”. Proteins are the workhorses of the cell; they play leading roles in the cell as enzymes, as structural components, and in cell signaling, to name just a few. DNA(deoxyribonucleic acid) is considered the “blueprint” of the cell; it carries all of the genetic information required for the cell to grow, to take in nutrients, and to propagate. RNA–in this role–is the “DNA photocopy” of the cell. When the cell needs to produce a certain protein, it activates the protein’s gene–the portion of DNA that codes for that protein–and produces multiple copies of that piece of DNA in the form of messenger RNA, or mRNA. The multiple copies of mRNA are then used to translate the genetic code into protein through the action of the cell’s protein manufacturing machinery, the ribosomes. Thus, RNA expands the quantity of a given protein that can be made at one time from one given gene, and it provides an important control point for regulating when and how much protein gets made.
For many years RNA was believed to have only three major roles in the cell–as a DNA photocopy (mRNA), as a coupler between the genetic code and the protein building blocks (tRNA), and as a structural component of ribosomes (rRNA). In recent years, however, we have begun to realize that the roles adopted by RNA are much broader and much more interesting. We now know that RNA can also act as enzymes (called ribozymes) to speed chemical reactions. In a number of clinically important viruses RNA, rather than DNA, carries the viral genetic information. RNA also plays an important role in regulating cellular processes–from cell division, differentiation and growth to cell aging and death. Defects in certain RNAs or the regulation of RNAs have been implicated in a number of important human diseases, including heart disease, some cancers, stroke and many others.

Is there life in the old dog yet?
An experiment with RNA and old dogs
By Wendy Volhard

Manfred my 25lb Standard wire-haired Dachshund was enjoying his 14th year when in the middle of the summer he had an ischemic event much like a stroke. Curled up to the right, with a slack jaw and right eye drooping, he obviously had suffered some neurological damage. Having had and been treated for liver disease his whole life, I did not feel I had too much of a chance of bringing him back to a life that had some quality. Never being afraid to
try, I put Manfred onto a special diet, gave him regular acupuncture treatments and chiropractic care. Over the next weeks, he slowly improved.

He could walk - albeit in a large circle - his eye returned to normal and the only residual damage seemed to be an inability to completely open his mouth. It never stopped him eating, however, and enjoying his food.

His main diet change was to use bison as a primary protein source, plus herbs that supported his liver, heart and circulation. It made a huge difference to his overall well-being and he managed to start walking in a straight line. Complete blood work was done at the end of January 2004. While triglyceride and lipase levels were lowered and the kidneys improved
over his previous tests, the rest of his blood looked alarming. He had elevated liver levels, alkaline phosphatase that was sky high, and cholesterol and total protein levels were at high normal. Something had to be done and soon.

Introduction to RNA
At the beginning of May a friend sent me newsletters from VRP, which contained articles about Ribonucleic Acid. These reports mentioned experiments with several old dogs in their teens, which were not in good shape. Just by adding RNA to their diets, the dogs had become puppy-like and lived many more years. With nothing to lose, I immediately ordered some.
For the first 14 weeks, I added 1/8th teaspoon to each morning meal. Manfred became livelier and insisted on returning to his long morning walks. Always bothered with impacted anal glands, on his regular monthly visit to his veterinarian three weeks later, the glands were no longer impacted. I was sent home with the admonition to continue whatever I was doing! The
following month's check-up revealed the same – no impaction. The vet noticed that the quality of Manfred's coat and skin was improving. The fuzzy soft coat that had replaced his wiry covering in his last years was turning a deep dark brown. His skin, which was wrinkly with flaky spots, was changing for the better. He seemed to be stronger.

With this success I introduced the same regimen to Manfred's half sister, Diggy, who was just turning 13½. I had had blood done on her a month before and was horrified to see that she seemed to be showing signs just like Manfred of elevated liver enzymes, alk phos levels very high, kidney reading just over high normal, lipase and cholesterol high. I was obviously battling some genetic disease. At a young age, both dogs were diagnosed with
hypothyroidism and were on thyroid medication. Diggy had the added complication of large fatty cysts under her left front leg, over her spleen and in between her shoulder blades. They were beginning to interfere with her forward mobility. At the end of July, we did a complete blood work-up on both dogs, consisting of a CBC and Chemistry Screen, plus a thyroid panel to see if there were any noticeable changes. When the blood tests were drawn, after a
12 hour fast, both dogs had been on 1/8th teaspoon of RNA daily in their morning meal for 14 weeks. Both dogs’ thyroid readings were too high after the 14 weeks on RNA and the
vet suggested I cut their medication by half.

It is interesting to note that the changes were different for each dog. Some levels went up for the female, but all levels listed went down for the male. I suspect their bodies were evening out and balancing in their own way. We are still working on reducing the Alk Phos levels. The large fatty cysts on Diggy began to diminish and today are hardly noticeable. After re-reading all the literature on RNA and noticing that the safety parameters were high, I decided to increase the RNA to 1/8th teaspoon twice a day. Both dogs are very lively, enjoy their food, their walks and are playing with the Labrador and Dachshund puppies in the family. Their
cognitive ability has increased and they are enjoying their newfound quality of life.

What is RNA?
Ribonucleic acid (RNA) is a substance obtained from Torula yeast. Grown on molasses and free of whole yeast cells, it is non-allergenic. Used extensively in the study of aging and chronic degenerative disease its pioneer, Dr Benjamin Frank, MD, researched and ran clinical experiments during the 1950s-70s. Many of his experiments were conducted on mice and
some o dogs. By supplementing their diets with RNA, he increased the life span of his experimental animals in a dramatic manner. Dr Frank believed that most diseases originate from some kind of cellular disorder or damage. He believed that diseased cells (and aging) could often be ‘cured’ by supplying the cells with an abundance of their basic building materials in pure form. The idea of the Nucleic Acid treatment is to supply cells with perfect,
undamaged nucleic acids that are the basic building blocks of DNA and RNA. Nucleic acids activate the processes of DNA repair in degenerative conditions by inducing enzyme synthesis and activation, and increasing energy producing processes in the cells. One of the key roles of RNA is protein synthesis.

Other successes with RNA:
Buoyed by the results with my own dogs, I wove this information into my conferences and seminars, and introduced RNA to many of my dog associates. They have reported the following:

An 11-year-old Labrador Retriever stud dog showed a dramatic increase in sperm count.

A seven year-old German Shepherd female that had shown signs of anxiety around other dogs and could be aggressive on occasion, showed a great calmness and an ability to socialize with other dogs.

A 10 1/2 year-old Labrador female who had had her cancerous spleen removed and given 2-3 weeks to live, 5 months later is still alive, all blood work is normal and she is racing around like a puppy.

A 19 year-old cat who was aging rapidly, had lost interest in food and was sleeping most of his life away, after several weeks on RNA is now charging around, playing, going outside and stalking in the grass. Coat has resumed its shine, and he shows increased mental capacity.

All the older dogs and cats that have had RNA added to their daily ration show signs of more energy and general overall vitality and cognitive ability.

So what is the answer to the title of this article? Is it possible to put
life into an old dog? In the case of my two Dachshunds, it is an
unqualified yes.

Ribonucleic Acid Part One

A Highly Effective Anti-Aging Supplement

By Ward Dean, MD
Durk Pearson and Sandy Shaw's 1982 bestselling book, Life Extension— A Practical, Scientific Approach (more than 2.5 million copies sold), is generally recognized as the spark that ignited the currently popular field of anti-aging/life extension medicine. Pearson and Shaw's blockbuster extolled the free radical theory of aging and introduced the terms free radicals and antioxidants to millions of non-scientist health enthusiasts. However, Pearson and Shaw's success was partially due to another popular book that helped to pave the way, which preceded their publication by six years.

In 1976, a pioneering New York medical doctor named Benjamin Frank created a minor sensation with his book—Dr. Frank's No-Aging Diet. Dr. Frank was unique. He was not only an MD, but also had a PhD in biochemistry. He was simultaneously a practicing physician and researcher, performing anti-aging experiments with mice and rats in addition to taking care of his patients.

Dr. Frank was ahead of his time. He was an early advocate of high-dose vitamin therapy (especially Bs, C, & E), plus other nutrients not well known or available in the early '60s through the mid-'70s when he did most of his research. For example, he recommended the use of carnosine, CoQ10, lipoic acid, DMG (then known as “Vitamin B15”), glycerol phosphate (magnesium glycerophosphate — he believed several grams per day promoted cell membrane integrity, and also restored receptors), vanadium, orotic acid, lecithin, choline, and inositol. A further indication of his foresight was his recommendation of the use of biguanide drugs like metformin, which is now becoming recognized as one of the most effective anti-aging drugs currently available (see my article, Metformin—An Effective and Underappreciated Life Extension Drug, in the November 1998 issue of Vitamin Research News).

Dr. Frank's Theory of Aging
Dr. Frank theorized that aging and degenerative diseases are caused by the loss of cellular energy production (ATP) due to membrane damage and decreased efficiency of the Kreb's cycle and the associated electron transport chain. He also believed that damage to cellular DNA from free radicals and crosslinkages could not be repaired due to inadequate cellular energy and availability of “raw materials” (i.e., nucleotides and nucleic acids [Fig.1.]) to repair the DNA. He believed that this decay of DNA further led to improper formation of messenger RNA and ribosomal RNA, which in turn led to abnormalities and structural defects in the cell. Frank's theory is clearly related to the mitochondrial, free radical, crosslinkage, and membrane theories of aging, all previously discussed in Vitamin Research News.

The key difference between Dr. Frank's theory and the approach used by advocates of the other related theories is the specific anti-aging therapy that he recommended—high-dose nucleic acids, combined with high potency multivitamins. Dr. Frank did not discount the approaches recommended by other researchers—he believed, however, that their methods (i.e., antioxidants, cross-linkage inhibitors) would not be effective unless combined with adequate amounts of RNA.

Dr. Frank believed that one cause of inadequate concentrations of RNA and nucleotides for repair and production of energy is an age-related increase in enzymes that destroy nucleic acids (i.e., nucleases—specifically, ribonuclease, which breaks down RNA). As people grow older, ribonuclease enzyme activity has been reported to increase. Consequently, just as the requirement to repair damaged cells increases, the substances required for this repair (nucleic acids) are being degraded by higher concentrations of destructive enzymes. Consequently, Dr. Frank believed older people have an even higher requirement for nucleic acids than younger people. Thus, the older we get, the greater our need for nucleic acids, both for replacement and for repair.

Nucleic Acids as Potential Life Extending, Disease-Preventing NutrientsDr. Frank believed that exogenous RNA, especially when combined with associated B vitamins, minerals, amino acids, and sugars (like D-ribose) would enter the cell and aid in normal regeneration of the damaged cellular elements. This would, in turn, bring about normal enzyme synthesis and activation, and most importantly would increase cellular energy production. For this reason, Frank believed that providing RNA and associated compounds would aid in the repair of damaged DNA. He knew that ribonucleic acid is important in the initiation of DNA synthesis, acting in a coenzyme-like fashion. Dr. Frank stated, “The importance of nucleic acids in protein synthesis and in enzyme synthesis, as well as the importance of RNA in bringing about DNA synthesis, and the actually observed anti-aging effects of nucleic acids on whole man, support the claims regarding the value of increased intake of nucleic acids in the prevention and treatment of cellular degeneration.”

Dr. Frank claimed that not only do nucleic acids (1) decrease overall oxygen utilization, but also (2) increase its inherent effectiveness, lessening potential oxidative damage to the cell. He believed that the “anti-anoxia effect” of nucleic acids (ability to do better work on less oxygen) was due to the increased synthesis of CoQ10 and enhancement of the efficiency of Kreb's cycle and respiratory chain. He believed nucleic acids might even lead to increased synthesis of mitochondria.

Effects of Nucleic Acids

  • Marked increase in “energy” or activity
  • Anti-anoxia action (i.e., reduced shortness of breath)
  • Increased ability to tolerate low temperatures
  • Decreased skin wrinkling and increased skin elasticity
  • Improved cognitive performance
  • Immune enhancement
  • Dr. Frank described the dramatic results of his use of oral and injectable ribonucleic acid in the prevention and treatment of a wide variety of age-related illnesses. He used a nucleic acid-rich diet and nucleic acid extracts for a variety of ills including emphysema, heart disease, diabetic complications, arthritis, fading eyesight, memory loss, and other diseases of aging. He believed that nucleic acids should be considered as essential nutrients, along with fats, carbohydrates, proteins, vitamins and minerals.
    Dr. Frank reported that a common finding of those on a high nucleic acid diet was a normalization of blood lipid levels. This was reflected by a drop in total cholesterol and triglycerides, and an elevation of HDL. He believed that the cholesterol-lowering effect of nucleic acid-rich diets was due to increased ATP formation, enhanced electron transport chain activity, improved CoQ10 and cytochrome oxidase synthesis, and increased NADH oxidation.

    He also reported that some of the earliest noticeable effects of RNA therapy were increased energy, followed by improved skin tone, with increased elasticity and reduction in fine wrinkles. He frequently referred to the skin-tightening effect, causing folds to diminish and the skin to acquire a tighter and more youthful appearance.
    Clinical Uses

  • Arthritis
  • Atherosclerosis
  • Hyperlipidemia
  • Cancer
  • Diabetes and complications
  • Emphysema
  • Colds
  • Glaucoma
  • Poor vision
  • Retinitis pigmentosa

  • Reduced skin wrinkles
  • Acne
  • Hair growth
  • Psoriasis
  • Diverticulitis
  • Memory loss
  • Parkinson's Disease
  • ALS
  • Bell's Palsy
  • Lupus erythematosus
  • Frank's dietary recommendations included:
    • Four days per week—eat one can of small sardines.
    • Eat fish on the other three days.
    • Calve's liver once/week
    • Lentils, peas, lima beans, or soybeans.
    • Asparagus, radishes, onions, scallions, mushrooms, spinach, cauliflower, or celery.
    • Seven glasses of fluid per day—4 of water, 2 milk, and 1 vegetable.
    While most modern nutritionists attribute the benefits of a high fish diet to the concentration of omega 3 fatty acids, Dr. Frank was of the opinion that it was primarily due to the high content of nucleic acids in most fish, and especially in sardines. (He did not discount the possible benefit of the omega 3 fatty acids, but believed that they were merely a synergistic adjunct to the nucleic acids.) He reported that sardines contain 1.5 percent nucleic acid, liver approximately 0.5 percent, and muscle meat 0.05 percent. Consequently, Dr. Frank had many anti-aging activists in the mid-'70s eating sardines like crazy. (Frankly, I got sick of eating sardine sandwiches!)

    Dr. Frank recommended consuming a minimum of 1.5 gm daily of nucleic acid for general health and well being. However, he recommended much higher doses for those with specific health concerns. He cautioned, however, that when taking higher therapeutic doses of RNA, that urine pH be only slightly in the acid range. He found that highly acidic urine with a high RNA diet (more than 2 gm daily) may result in elevated levels of uric acid in the blood, which can cause kidney stones. This can be easily prevented by drinking plenty of water. Urine acid-base balance (pH) can be easily tested by using urine pH test strips.

    Clinically, Dr. Frank used dosages of RNA between 500 mg-20 gm. He usually recommended the higher doses (over 5 grams) be used several times per week. If dosages higher than 2 gm daily were taken, Dr. Frank recommended doing so under the care of a physician, where BUN, creatinine and uric acid levels could be monitored, and recommended that the urine pH be maintained near 6 (i.e., between 5.0-7.0). Dr. Frank stated that those with uric acid of 2-3 mg can take considerably larger amounts of nucleic acid than those with levels closer to 5, 6, or 7 mg. Higher amounts of uric acid can be better tolerated in near alkaline urine than in very acid urine. It should be noted that he never observed any problems in people with normal kidney function, who drank adequate fluids and maintained urine pH in the desired range. He recommended that additional protection could be gained by consuming adequate amounts (500-1,000 mg) of magnesium each day.

    Historical Basis of RNA as an Anti-Aging Supplement
    Dr. Frank was not the first to experiment with nucleic acids. In 1908, Dr. C.S. Minot first proposed that nucleic acids were vital for the health of cells and were essential for the longevity of the organism. However, the first evidence that nucleic acids might actually promote longevity was demonstrated by a series of experiments conducted by Dr. T. Brailsford Robertson in Australia in 1928. Dr. Robertson believed that the lifespan of organisms was determined by the ratio of nuclear (chromosomal) materials to the cytoplasm (protein) of the cells. He referred to this ratio as the “nucleocytoplasmic ratio”—and proposed that the way to optimize this ratio was to supply the nuclei of the organism with nutrients in “excessive abundance.”
    He tested his hypothesis in a series of experiments. He used 30-40 male and 30-40 female mice in each test group, with a similar group of controls in each experiment. The test groups received 25 mg of yeast nucleic acid each day throughout their lives. Robertson's hypothesis was apparently confirmed, as the results were strikingly and uniformly positive. He reported an average lifespan extension of 12.5 percent for males, and 17 percent for females (Fig. 3).

    Despite these positive, provocative results, almost twenty years elapsed before any further research was done in this area. In the mid-1940s, Dr. Thomas Gardner, an organic chemist in the scientific department of Hoffman-La Roche, picked up where Robertson had left off. Gardner agreed with Robertson's hypothesis that the nucleocytoplasmic ratio decreased with aging, but was not convinced that correcting this ratio was the mechanism of RNA's life-prolonging effects. He proposed several other possible mechanisms for these benefits. He suggested that nucleic acids might slow down the metabolism of the nucleus of the cell. He reasoned that if nucleic acids were provided to the cell in high amounts, they could be utilized in metabolism without destroying the nucleus or cytoplasm, and thereby enable the cells to live longer at a higher energy level. Alternatively, he theorized that the life-prolonging effect of yeast nucleic acid might be due to its ability to stimulate the immune system, since sodium yeast nucleinate was known to stimulate the growth and proliferation of white blood cells (leukocytes). He equated this to the proposed anti-aging effects of Anti-Reticulo Cytotoxic Serum (ARCS) then being used in Russia (Bogomolets). ARCS was briefly reviewed in the August, 2003 issue of Vitamin Research News.

    Whatever the mechanism, Gardner attempted to replicate Robertson's work, with several modifications. First, he began his studies with mice that were 600 days old (instead of beginning treatment after weaning, as Robertson had done), because “mice are beginning to get old at that age.” Also, he believed that Robertson's dosages were unrealistically high. He calculated that 25 mg per mouse per day would translate into a human dose of 55 gm per day. Gardner was apparently considering human use of RNA, and realized that few humans could consume such high doses. Consequently, Gardner administered 1/10th of the dosage used by Robertson, resulting in a daily RNA dosage of 2.5 mg per mouse per day. This corresponded to an equivalent human dosage of 5.5 grams per day, which Gardner believed could be practically consumed.
    Gardner used 72 female and 31 male albino mice, divided into test and control groups. Gardner reported that the treated mice retained vitality and vigor longer than the controls, fewer went blind, and the treated mice appeared healthier and exhibited greater activity than the controls. Although the lifespan extension of the mice receiving nucleic acids was not as great as reported by Robertson, there was an overall trend toward increased longevity in the nucleic acid-treated mice. Gardner attributed his less spectacular results to the fact that he started the experiment when the mice were already advanced in age, and that the dosage was so much less than that administered by Robertson.

    Interestingly, Gardner reported that Robertson and his staff had taken 15 gm yeast nucleic acid per day, and that Gardner himself (perhaps as a result of observing his healthy mice) had been taking 5 gm of yeast nucleic acid for weeks “without any ill effects.” He concluded that “As Robertson tested with three times the amounts I have suggested for [human] use, there is no reason known at the present time for fearing to use yeast nucleic acid freely for veterinary experimental purposes…and…for extending their life spans as well as for experimental therapy on aging men and women for the same purpose.”

    Nearly another twenty years were to elapse before further experiments with RNA were conducted—this time with even more spectacular results. Dr. Max Odens conducted a study with ten 750-day-old rats, of a species that had a normal lifespan of 800-900 days. Five rats were untreated controls. The other five received weekly injections of “DNA solution in water…plus ordinary RNA.” Unfortunately, details of the exact composition and dosage that was administered were not given. After twelve weeks of injections, Odens reported that the treated rats looked younger, were very lively, and had gained weight, in contrast to the untreated rats which “looked old, moved slowly, did not eat much, and had lost weight. The difference was remarkable.” Odens further reported that all of the untreated rats died before 900 days, while 4 of the treated rats survived between 1600 and 1900 days, and one rat lived 2250 days! Odens concluded that “with weekly injections of DNA and RNA, the life span of 4 rats was doubled on the average, and the life span of the fifth rat was more than trebled.” These results are frankly, hard to believe. But some credence must be given this report, considering the journal in which it was published—the prestigious Journal of the American Geriatrics Society.

    The claims for the life-extending benefit of nucleic acid administration are supported by a diverse series of experiments that span nearly 50 years. Based on these findings and the reports by Dr. Frank of its widespread clinical benefits with human use, I consequently agree with Dr. Frank's recommendation to add at least 1.5 grams per day of nucleic acids to an anti-aging nutritional supplement regimen. This recommendation is buttressed by the facts that two of the research teams admitted taking high dose nucleic acids themselves, after seeing the effects they had on their experimental animals, and that the third researcher also recommended consideration of nucleic acid supplementation for human and veterinary use. It is surprising that more researchers have not attempted to replicate these studies—especially when considering the high degree of safety and minimal cost of high quality yeast-derived nucleic acids that are available today. :
    1. Minot, C.S., The Problem of Age, Growth and Death, G.P. Putnam's Sons, 1908, New York.
    2. Frank, G. Nucleic Acid Therapy in Aging and Degenerative Disease—A Metabolic Approach with DNA, RNA and Related Metabolites, Psychological Library, New York, 1968.
    3. Frank, B. Dr. Frank's No-Aging Diet. The Dial Press, New York, 1976.
    4. Frank, B. Nucleic Acid & Antioxidant Therapy of Aging & Degeneration. Royal Health Books, Ltd, Long Island, NY 1977.
    5. Robertson, T. Brailsford. On the influence of nucleic acids of various origin upon the growth and longevity of the white mouse. Australian J Exp Biol Med Sci, 1928, 5: 47-67.
    6. Gardner, T. The effect of yeast nucleic acid on the survival time of 600 day old albino mice. J Gerontol, 1946, 1: 445-456.
    7. Odens, M. Prolongation of the life span in rats. J American Geriatrics Soc, 1973, XXI: 450-451.
    8. Bogomolets, A.A. Anti-reticular cytotoxic serum as a means of pathogenic therapy, Am Rev Soviet Med, 1943, 1: 101-112.

    Ribonucleic Acid Part Two

    Review of Potential Anti-Aging Effects

    By Ward Dean, MD
    In 2003 the scientific community celebrated two important milestones. First, April 2003 was the 50th anniversary of the discovery of the structure of DNA, revealed by James Watson and Francis Crick to be a double helix. Second, 2003 marked the year the human genome was successfully sequenced by the Human Genome Project (HGP).

    The half-century between these two events was a period enriched by the collective insights and hard work of a number of brilliant research scientists devoted to unlocking the mysteries of DNA. One of the leading members of this august body was Dr. Benjamin Frank. Dr. Frank deserves a great deal of credit for his pioneering insight and work in originating nucleic acid therapy to treat aging and degenerative diseases with oral doses of RNA. Dr. Frank intensively experimented with nucleic acids from 1961 until his untimely death in 1979. His early work involved the study of the physiologic effects of RNA and RNA + DNA. He found that these substances had profound (1) anti-aging (including reduced skin wrinkling and increased skin elasticity); (2) energizing; (3) “anti-anoxia” (oxygen sparing); (4) anti-low temperature and freezing [as evidenced by increased survival of experimental animals subject to low temperatures]; (5) anti-viral; and (6) cognitive enhancing effects.

    These effects were first reported in his book A New Approach to Degenerative Disease and Aging—Effect of RNA, DNA with Other Metabolites (1964), and were subsequently elaborated upon in his later books, Nucleic Acid Therapy in Aging and Degenerative Disease (A Metabolic Approach with DNA, RNA and Related Metabolites) (1969), Dr. Frank's No Aging Diet (1976), and Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration (1977). Although Dr. Frank's observations remain largely uninvestigated by other scientists, they are summarized here as a potential adjunctive approach to alleviating a variety of conditions, ranging from cosmetic and bothersome symptoms to life-threatening illnesses.
    Dr. Frank's nucleic acid treatments contained from 300 mg to several grams of RNA and DNA, taken daily along with a high-potency multi-vitamin, multi-mineral formulation. Remarkable improvements were often obtained, ranging from increased mental alertness and physical performance, to decreased wrinkles.

    Integrated Theory of Aging
    Dr. Frank's publications were not just a compilation of his observations, but outlined an integrated theory of aging. His theory was that nucleic acids, when injected or ingested, led to a marked increase in enzyme synthesis and activation. These actions are enhanced when optimum amounts of associated coenzymes (vitamins) and cofactors (minerals) and substrates are present or administered along with the nucleic acids. Dr. Frank envisioned the whole system of metabolites as being active in RNA therapy, but believed the nucleic acids were the most critical part of this regimen.
    Most diseases originate from some kind of cellular disorder or damage. Dr. Frank believed that diseased cells (and aging) could often be “cured” by supplying the cells with an abundance of their basic building materials in pure form. The idea of the “Nucleic Acid Treatment” is to supply cells with perfect, undamaged nucleic acids, which are the basic building blocks of DNA and RNA. Nucleic acids activate the processes of DNA repair in degenerative conditions by inducing enzyme synthesis and activation, and increasing the energy-producing processes in the cell.

    Dr. Frank believed that it should be possible, by activation and synthesis of proper enzymes, to repair cellular and sub-cellular damage with some degree of precision. This is a point which no one working with nucleic acids has properly developed. It also helps to explain why DNA damaged in degenerative diseases and aging is repaired by the type of nucleic acid therapy which he recommended.
    Frank proposed that rejuvenation could occur if large quantities of pure RNA and DNA were consumed and then incorporated into our own RNA and DNA. (This probably happens when cells divide and new DNA and RNA is formed). The replacement of “old” nucleic acids with “young” nucleic acids represents an overall improvement in, or repair of, our DNA and RNA. Since DNA and RNA are the key molecules for the efficient performance of the cells (and the entire body), an overall improvement of all cell processes should result, as Dr. Frank observed in patients treated with nucleic acids.

    Dr. Frank was aware that the number and quality of mitochondria decreased with aging. He believed that nucleic acids may lead to increased synthesis of mitochondria, as well as enhanced repair of mitochondrial damage, thereby resulting in the increased energy production seen with RNA treatment. Dr. Frank first described the anti-anoxia effect of exogenous nucleic acids in his book, A New Approach to Degenerative Diseases and Aging (1964), which he believed was due to increased electron transport chain activity, resulting from increased ATP synthesis and turnover. Frank also believed that aging was due to a decay of DNA, occasioned by the breakdown of lysosomal membranes and subsequent release of destructive enzymes that cause DNA to decay. This breakdown of DNA leads to improperly formed messenger RNA. With advancing age, defective messenger RNA molecules are formed, causing subsequent errors in protein synthesis. If the improperly formed protein molecules are enzymes, they may either fail to perform their essential chemical reactions in cells, or do so at reduced rates.

    In any event, the result would be an accumulation of the substrates on which the enzymes act. Because of the feedback mechanisms which operate in cells, this accumulation of substrates could stimulate an increased production of defective messenger RNA and enzymes. When such an increase does not permit production of adequate amounts of normal enzymes, the cell dies. Nucleases are enzymes in the body that destroy nucleic acids. Ribonuclease (RNAase) breaks down RNA. Levels of ribonuclease increase as we grow older, resulting in increased destruction of RNA. This explains why older people need larger amounts of RNA. Aging, or decay in cells, may precede this increase in RNAase activity so that RNA itself is liberated. This liberated and possibly denatured RNA (or RNA-containing compounds) may induce increased RNAase formation and, once formed, this RNAase activity returns to accelerate the aging process.
    Basic to Dr. Frank's approach is the theory that exogenous RNA, when combined with metabolically associated B vitamins, minerals, amino acids and sugars, will enter the cell and aid in normal regeneration of the decayed metabolic organization of the cell and in so doing will bring about normal enzyme synthesis and activation.

    Although Frank was aware of and respected the work of other pioneers in anti-aging research like Denham Harman (Denham Harman and the History of the Free Radical Theory of Aging, VR News, Aug. 2002), and Johan Bjorksten (Crosslinkage Theory of Aging, VR News, Jan. 2002), he believed that the key to retarding or reversing aging—whatever the cause—lay in repairing the damage involved at the points or places of involvement. And it is here that nucleic acid-containing repair systems must be primarily involved. He believed that the nucleic acid containing metabolic system appears to offer the best hope of repairing the increasing damage caused by the aging process.
    To retard aging, he believed it was important to increase the quantity of nucleic acids in the diet, along with a broad spectrum of vitamins, minerals and trace minerals, and to follow a diet containing sufficient high quality protein and unsaturated fatty acids. Dr. Frank believed that if the optimum dosage of nucleic acids were taken, it would double or triple the present life span, if experience in animals was any indication.

    Nucleic Acid Therapy for Aging and the Diseases of Aging
    Aging Reversal
    Dr. Frank claimed that nucleic acid therapy resulted in a definite, but incomplete, reversal of many of the degenerative processes of aging. He believed that the observed results of aging reversal obtained with nucleic acids (and other nutritional factors) pointed the way to an attainable goal of reversing the biological age of an 80 year old man by 40 to 50 years. Frank stated optimistically, “Indeed, when total reversal of aging is achieved there would seem to be no reason why an indefinitely long and healthy life is not possible.”
    Dr. Frank reported on his experiences in increasing the life expectancy of two dogs treated with RNA. One dog was a mongrel aged 14 years, and the other was a 16-year-old Chihuahua. Both dogs were nearly blind, with hair that was dry, brittle and scanty, and suffered from arthritis and “myocardial weakness.” From their appearance, their future life expectancy was estimated by a veterinarian to be months, at the most. Dr. Frank treated both dogs with RNA (8 gm daily for the younger dog, and 4 gm daily for the older dog), along with B complex and cod liver oil daily. The health of both dogs improved dramatically after one month, activity increased, and their coats became much softer and fuller. The younger dog died in an automobile accident at age 20, and the older dog succumbed at age 23 from an infestation of intestinal worms. Dr. Frank reported that both dogs were in excellent health immediately prior to these final episodes, and believed that their lives were definitely extended by the RNA therapy.

    Anti-Aging Effect of RNA on Skin
    One of the most visible effects of aging is the wrinkling of skin. Other skin changes include a loss of elasticity and thinning of the skin, accompanied by the loss of fat and water. In human studies, Dr. Frank reported that “the most striking effects were observed on the skin of the face….the higher the dosage, the more rapidly these effects were observed. The first changes appeared to be alterations in skin …toward a healthier, rosier looking skin, with an apparent smoothening of the skin of the face, without any change yet in wrinkles and lines…. When dosages as low as 500 to 1,000 mg RNA daily were used, these early changes occurred in about 2 to 3 weeks. When doses of 5 grams daily were used, these changes occurred within the first week.
    After one to two months of treatment, there not only was an increase in smoothness and color of the skin, but lines and wrinkles began to diminish. The wrinkles in the forehead were often the first to decrease in depth. Those of the nasolabial fold appeared to take longer. The lines around the eyes took longer still to decrease in depth….”

    Concurrent with the observed decreases in skin wrinkling Dr. Frank observed increases in skin tightness, which he believed were an important cause of the smoothening of the skin, along with increased hydration.
    A standard test of aging of skin is to measure the time it takes for the skin of the dorsum of the hand to return to its normal condition after being “pinched” (Figs. 1 and 2). Three to four months of RNA treatment resulted in a more rapid return to normal in the majority of patients tested. Frank reported that after 15 patients (6 males and 9 females, varying in age from 40 to 71 years) were administered 5 grams of RNA daily for three months, the time it took for skin to return to normal after being pinched decreased by 30 to 40 percent. Wrinkles of the forehead were also noticeably reduced after 2 to 4 months of treatment. Dr. Frank estimated that the improved appearance of the skin resulted in an apparent decreased age by ten years or more in older patients (those over 70).

    Dr. Frank reported that “liver spots” often disappeared after approximately two months of oral nucleic acid therapy, accompanied by tightening of the skin, causing folds to diminish and giving skin a tighter, more youthful appearance. In addition to the obvious improvements in skin appearance and elasticity, these changes indicate potentially beneficial effects on internal organs as well.

    Dr. Frank noted other skin changes due to RNA therapy, including a gradual decrease in size and pigmentation of senile keratoses (wart-like skin lesions), beginning two to four months after initiating RNA therapy. This occurred with doses of RNA ranging from 1-3 gm daily.
    Frank also noted reduced dryness of the skin, and an improvement in acne in younger people.
    Next Month
    Part III of RNA: A Highly Effective Anti-Aging Supplement will review the anti-aging and health benefits of Dr. Frank's Ribonucleic Acid Therapy in relation to cancer, diabetes, coronary heart disease, energy production, and related disorders of aging.